A: Average lower limb pain scores over time for 10-kHz SCS + CMM participants ( n = 84, left) and CMM participants with crossover after 6 months ( n = 58, right). Pain and neurological results over 12 months. All follow-up assessments were compared with baseline, and the investigator categorized motor, reflex, and sensory separately as “improvement,” “no change,” or “deficit.” Overall neurological improvement was defined as an improvement in motor, reflex, or sensory function without a deficit in any category. Assessment included motor strength and reflex testing as well as sensory testing for light touch, pinprick, and 10-g monofilament. C: Proportion of participants over time who investigators reported to have improvement on neurological examination for 10-kHz SCS + CMM participants ( n = 76, left) and CMM participants with crossover after 6 months ( n = 52, right). B: Proportion of pain responders, defined as those with at least 50% pain relief from baseline, at 3, 6, 9, and 12 months for 10-kHz SCS + CMM participants ( n = 84, left) and CMM participants with crossover after 6 months ( n = 58, right). Participants rated pain on a 10-cm VAS, with 0 representing “no pain” and 10 being the “worst pain imaginable.” Left and right lower limbs were each rated separately, and the scores were averaged together for each participant. Mekhail Durability of High-Frequency 10-kHz Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy Refractory to Conventional Treatments: 12-Month Results From a Randomized Controlled Trial. Guirguis, Jijun Xu, Cong Yu, Ali Nairizi, Denis G.
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